4-aminopyridine restores visual ocular motor function in upbeat nystagmus
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چکیده
منابع مشابه
4-aminopyridine restores visual ocular motor function in upbeat nystagmus.
The effect of the potassium channel blocker 4-aminopyridine (4-AP) on spontaneous upbeat nystagmus (UBN) was investigated with the search coil technique during fixation in different gaze positions and smooth pursuit in a patient before and after ingestion of 10 mg 4-AP. UBN was reduced from 8.6 deg/s to 2.0 deg/s by 4-AP causing subjective relief from distressing oscillopsia, and impaired upwar...
متن کامل4-aminopyridine restores vertical and horizontal neural integrator function in downbeat nystagmus.
Downbeat nystagmus (DBN), the most common form of acquired fixation nystagmus, is often caused by cerebellar degeneration, especially if the vestibulo-cerebellum is involved. The upward ocular drift in DBN has a spontaneous and a vertical gaze-evoked component. Since cerebellar involvement is suspected to be the underlying pathomechanism of DBN, we tested in 15 patients with DBN whether the app...
متن کاملPrimary position upbeat nystagmus in Wernicke's encephalopathy.
for morbid obesity. In the subsequent 4 months, he suffered from recurrent and intense vomiting, losing 40 kg. Asymptomatic hypokalemia and hypomagnesemia were discovered and supplemented. At this time, systematic oral vitamin therapy was begun. One month later, he started to describe blurred vision and vertical oscillopsia. Neurological examination revealed ataxia and nystagmus. Standard biolo...
متن کاملUpbeat Nystagmus: Clinicoanatomical Correlations in 15 Patients
BACKGROUND AND PURPOSE The mechanism of upbeat nystagmus is unknown and clinicoanatomical correlative studies in series of patients with upbeat nystagmus are limited. METHODS Fifteen patients with upbeat nystagmus received full neuro-ophthalmological evaluation by the senior author. Nystagmus was observed using video Frenzel goggles and recorded with video-oculography. Brain lesions were docu...
متن کامل4-Aminopyridine restores impaired hypoxic pulmonary vasoconstriction in endotoxemic mice.
BACKGROUND Hypoxic pulmonary vasoconstriction (HPV) is impaired during inflammatory lung processes such as pneumonia or the acute respiratory distress syndrome. Voltage-gated potassium channels play a central role in mediating HPV. The aim of this study was to determine whether 4-aminopyridine (4-AP), a known voltage-gated potassium channel inhibitor, may restore HPV in sepsis. METHODS The ef...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 2005
ISSN: 0022-3050
DOI: 10.1136/jnnp.2004.045716